Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism
نویسندگان
چکیده
منابع مشابه
Lead optimization of HMBA to develop potent HEXIM1 inducers.
The potency of a series of Hexamethylene bis-acetamide (HMBA) derivatives inducing Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) was determined in LNCaP prostate cancer cells. Several compounds with unsymmetrical structures showed significantly improved activity. Distinct from HMBA, these analogs have increased hydrophobicity and can improve the short half-life of HMBA, which is one ...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2016
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2016.05.029